STUDIES ON ABNORMAL HEMOGLOBIN

The Abnormal Hemoglobin Syndromes

By IRwIN 1\i. WEINSTEIN, CARROLL L. SPURLING, HERMAN I’tLEIN AND THOMAS F. XECHELES I x PREVIOUS PUBLICATIONS,’ ,2 1e have reported that tagging human erythrocytes with radioactive chromium in the form of Na2Cr”O4 affords a simple, rapid and reproducible method for studying the survival of erythrocytes in normal subjects and patients with various hernatologic disturbances. By this method the on...

Studies on Abnormal

Recently, ithas been demonstrated thatthe offspring of one parent with the sickle cell trait and one w’ith thalassemia may develop a severe hemolytic anemia with some of the characteristics of both thalassemia and sickle cell disease, ineluding microcytosis and numerous sickled erythrocytes in the blood film. This syndrome has been called mi(’rodrepanocytic,9 or sickle cell-thalassemia, disease...

Fetal Hemoglobin with Abnormal ‘ Y . Polypeptide Chains : Hemoglobin Warren

By T. H. J. HUISMAN, A. M. Dozy, B. E. HORTON AND J. B. WILsON T HE EXISTENCE of variants of normal human fetal hemoglobin ( HbFor a2y2 ) has been suggested in different reports in the literature. Variants of fetal hemoglobin with abnormal a-polypeptide chains have been described5 ”5 and some are well characterized.’0 Only one abnormality, namely the electrophoretically fast moving hemoglobin v...

Studies on the Fetal Hemoglobin of Rabbits.

Since KORBER1) discovered in 1865 that human fetal hemoglobin is more resistant to alkali than the adult one, numerous works indicating differences in properties of the fetal and the adult pigment have been published . Biochemically, a considerable dissimilarity is found in their amino acid compositions and primary structures, i. e. amino acid sequences2). Physiologically , it has long been kno...

Studies on Hemoglobin Biosynthesis: Asynchronous Synthesis of Hemoglobin a and Hemoglobin A2 by Erythrocyte Precursors.